Search Ontology:
ChEBI

linsitinib

Term ID
CHEBI:91402
Synonyms
  • ASP-7487
  • cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol
  • cis-3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol
  • linsitinib
  • linsitinibum
  • OSI 906
  • OSI 906AA
  • OSI-906
  • OSI-906AA
  • OSI906
(all 10)
Definition
An imidazopyrazine that is imidazo[1,5-a]pyrazine substituted by 2-phenylquinolin-7-yl, cis-3-hydroxy-3-methylcyclobutyl, and amino groups at positions 1, 3, and 8, respectively. It is dual inhibitor of the IGF-1 receptor and insulin receptor (IC50 = 35 and 75 nM, respectively) that was previously in clinical development for the treatment of cancer and thyroid eye disease.
References
(all 37)
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from linsitinib
Phenotype where environments contain linsitinib
Phenotype modified by environments containing linsitinib
Phenotype affecting linsitinib
Human Disease Model
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