ZM447439

Term ID

CHEBI:91376

Synonyms

N-(4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinazolinyl)amino)phenyl)benzamide
N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
N-[4-[[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]amino]phenyl]benzamide
ZM 447439
ZM-447439
ZM447439

Definition

A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC₅₀ of 110 nM and 130 nM, respectively.

References

cas:331771-20-1
lincs.smallmolecule:LSM-1096
pdb-ccd:447
pdb:2VRX
pubmed:12719470
pubmed:15616188
pubmed:18367484
pubmed:18418083
pubmed:18559266
pubmed:19298889
pubmed:19686703
pubmed:19923785
pubmed:21099354
pubmed:21159048
pubmed:21775627
pubmed:23613471
pubmed:24152827
pubmed:24680981
pubmed:24748653
pubmed:29147452
wikipedia.en:ZM447439

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from ZM447439

Phenotype where environments contain ZM447439

Phenotype modified by environments containing ZM447439

Phenotype affecting ZM447439

Human Disease Model