Search Ontology:
ChEBI

GW843682X

Term ID
CHEBI:91334
Synonyms
  • 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
  • 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide
  • 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide
  • GW 843682X
  • GW-843682X
  • GW843682
Definition
A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively).
References
  • cas:660868-91-7
  • lincs.smallmolecule:LSM-1014
  • pubmed:17267659
  • pubmed:18616938
  • pubmed:19421227
  • pubmed:21436619
  • pubmed:21474997
  • pubmed:21637161
  • pubmed:23792639
  • pubmed:24205328
  • pubmed:26055176
  • pubmed:27198987
  • pubmed:36591293
  • pubmed:37181811
  • pubmed:38614382
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from GW843682X
Phenotype where environments contain GW843682X
Phenotype modified by environments containing GW843682X
Phenotype affecting GW843682X
Human Disease Model