GW843682X

Term ID

CHEBI:91334

Synonyms

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide
GW 843682X
GW-843682X
GW843682

(all 6)

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively).

References

(all 15)

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes aromatic ether benzimidazoles primary carboxamide thiophenes

(trifluoromethyl)benzenes aromatic ether benzimidazoles primary carboxamide thiophenes Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor

antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from GW843682X

Phenotype where environments contain GW843682X

Phenotype modified by environments containing GW843682X

Phenotype affecting GW843682X

Human Disease Model