sertraline

Term ID

CHEBI:9123

Synonyms

(+)-sertraline
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
(1S,4S)-sertraline
(1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine
cis-(+)-sertraline
CP 51974
sertralina
sertraline
sertralinum

(all 9)

Definition

A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.

References

CAS:79617-96-2
DrugBank:DB01104
Drug_Central:2436
HMDB:HMDB0005010
KEGG:C07246
KEGG:D02360
LINCS:LSM-3843
PDBeChem:SRE
PMID:19502000
PMID:21823671
Patent:US4536518
Reaxys:5753709
Wikipedia:Sertraline

(all 13)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

inverse is_conjugate_acid_of: Show First 5 Terms Show All Terms
has_role: Show First 5 Terms Show All Terms
has_parent_hydride: Show First 5 Terms Show All Terms
is_conjugate_base_of: Show First 5 Terms Show All Terms
is a type of: Show First 5 Terms Show All Terms

Phenotype

Phenotype resulting from sertraline

Phenotype where environments contain sertraline

Phenotype modified by environments containing sertraline

Phenotype affecting sertraline

Human Disease Model