Search Ontology:
ChEBI
MCB-613
- Term ID
- CHEBI:90954
- Synonyms
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- (2E,6E)-4-ethyl-2,6-bis(3-pyridylmethylene)cyclohexan-1-one
- (2E,6E)-4-ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
- MCB 613
- MCB613
- Definition
- A cyclic ketone that is 4-ethylcyclohexanone which is substituted by pyridin-3-ylmethylene groups at positions 2 and 6. It is a potent small molecule stimulator of steroid receptor coactivators (SRCs). MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species. Since cancer cells overexpress SRCs and rely on them for growth, MCB-613 can be used to selectively induce excessive stress in cancer cells.
- References
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- PMID:26267537
- Patent:WO2008144011
- Reaxys:25955891
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from MCB-613
Phenotype where environments contain MCB-613
Phenotype modified by environments containing MCB-613
Human Disease Model