alectinib

Term ID

CHEBI:90936

Synonyms

• 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
• AF 802
• AF-802
• alectinib
• CH 5424802
• CH5424802

Definition

An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydrochloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.

References

• cas:1256580-46-7
• drugcentral:4937
• kegg.drug:D10542
• lincs.smallmolecule:LSM-1202
• pdb-ccd:EMH
• pubmed:24736079
• pubmed:24887559
• pubmed:25205428
• pubmed:25228534
• pubmed:25349307
• pubmed:25398579
• pubmed:25428710
• pubmed:25502629
• pubmed:25526238
• pubmed:25556163
• pubmed:25678258
• pubmed:25736571
• pubmed:25876560
• pubmed:26464158
• pubmed:26487585
• pubmed:26579422
• pubmed:26682573
• pubmed:26739884
• pubmed:26751586
• pubmed:26752591
• pubmed:26753004
• reaxys:22302431
• wikipedia.en:Alectinib

Ontology

ChEBI  ( EBI )