rolapitant

Term ID

CHEBI:90908

Synonyms

(5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
rolapitant
SCH 619734
SCH-619734

Definition

An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: azaspiro compound ether organofluorine compound piperidines pyrrolidin-2-ones

azaspiro compound ether organofluorine compound piperidines pyrrolidin-2-ones Show first 5 Terms
has_role: antiemetic neurokinin-1 receptor antagonist

antiemetic neurokinin-1 receptor antagonist Show first 5 Terms
inverse is_conjugate_acid_of: rolapitant(1+)

rolapitant(1+) Show first 5 Terms
is_conjugate_base_of: rolapitant(1+)

rolapitant(1+) Show first 5 Terms

Phenotype

Phenotype resulting from rolapitant

Phenotype where environments contain rolapitant

Phenotype modified by environments containing rolapitant

Human Disease Model