tipiracil

Term ID

CHEBI:90879

Synonyms

5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione
tipiracil

Definition

A member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: carboxamidine organochlorine compound pyrimidone pyrrolidines

carboxamidine organochlorine compound pyrimidone pyrrolidines Show first 5 Terms
has_functional_parent: uracil

uracil Show first 5 Terms
has_role: antineoplastic agent EC 2.4.2.4 (thymidine phosphorylase) inhibitor

antineoplastic agent EC 2.4.2.4 (thymidine phosphorylase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: tipiracil(1+)

tipiracil(1+) Show first 5 Terms
is_conjugate_base_of: tipiracil(1+)

tipiracil(1+) Show first 5 Terms

Phenotype

Phenotype resulting from tipiracil

Phenotype where environments contain tipiracil

Phenotype modified by environments containing tipiracil

Human Disease / Model Data

Citations