cobimetinib

Term ID

CHEBI:90851

Synonyms

• [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
• cobimetinib
• GDC 0973
• GDC-0973
• GDC0973
• RG 7420
• RG7420
• Xl 518
• Xl-518
• XL518

Definition

A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.

References

• cas:934660-93-2
• drugbank:DB05239
• drugcentral:5046
• kegg.drug:D10405
• pdb-ccd:EUI
• pubmed:24589925
• pubmed:25037139
• pubmed:25142409
• pubmed:25243894
• pubmed:25265494
• pubmed:25444546
• pubmed:25813936
• pubmed:26365290
• pubmed:26384788
• pubmed:26451002
• pubmed:26452567
• reaxys:12883594
• wikipedia.en:Cobimetinib

Ontology

ChEBI  ( EBI )