Search Ontology:
ChEBI

cobimetinib

Term ID
CHEBI:90851
Synonyms
  • [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
  • cobimetinib
  • GDC 0973
  • GDC-0973
  • GDC0973
  • RG 7420
  • RG7420
  • Xl 518
  • Xl-518
  • XL518
Definition
A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
inverse is_conjugate_acid_of
is_conjugate_base_of
Phenotype
Phenotype resulting from cobimetinib
Phenotype where environments contain cobimetinib
Phenotype modified by environments containing cobimetinib
Human Disease Model
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