BMS-453

Term ID

CHEBI:90739

Synonyms

• 4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid
• BMS 189453
• BMS 453
• BMS-189453
• BMS189453
• BMS453

Definition

A member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor γ (RARβ) agonist that acts as an antagonist against RARα and RARγ.

References

• cas:166977-43-1
• pubmed:12563696
• pubmed:21107276
• pubmed:22423954
• pubmed:24720764
• pubmed:26469117
• pubmed:27261179
• reaxys:24186643

Ontology

ChEBI  ( EBI )