torkinib

Term ID

CHEBI:90679

Synonyms

• 2-(4-Amino-1-isopropyl-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-1H-indol-5-ol
• 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
• PP 242
• PP-242
• PP242

Definition

A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.

References

• cas:1092351-67-1
• hmdb:HMDB0060607
• pdb-ccd:P2X
• pubmed:23542178
• pubmed:23636326
• pubmed:24316308
• pubmed:25035961
• pubmed:25188886
• pubmed:25239638
• pubmed:25415435
• pubmed:25440763
• pubmed:25535978
• pubmed:26163195
• pubmed:26548560
• pubmed:26586952
• pubmed:26636543
• pubmed:26719046
• reaxys:11730137

Ontology

ChEBI  ( EBI )