Search Ontology:
ChEBI
PLX-4720
- Term ID
- CHEBI:90295
- Synonyms
-
- N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide
- N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
- PLX 4720
- PLX4720
- Definition
- A pyrrolopyridine that is vemurafenib in which the p-chlorophenyl group has been replaced by chlorine. It is a potent and selective inhibitor of the Raf kinase B-Raf(V600E).
- References
-
- cas:918505-84-7
- lincs.smallmolecule:LSM-1049
- pdb-ccd:324
- pubmed:20818433
- pubmed:21088259
- pubmed:21134546
- pubmed:21355020
- pubmed:21738740
- pubmed:22858545
- pubmed:22941213
- pubmed:24735766
- pubmed:25544599
- pubmed:26347528
- pubmed:26456124
- reaxys:12833018
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from PLX-4720
Phenotype where environments contain PLX-4720
Phenotype modified by environments containing PLX-4720
Phenotype affecting PLX-4720
Human Disease Model