tiazofurine

Term ID

CHEBI:90239

Synonyms

• (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
• 2-(beta-D-ribofuranosyl)-4-thiazolecarboxamide
• 2-beta-D-ribofuranosyl-4-thiazolecarboxamide
• CI-909
• riboxamide
• TCAR
• tiazofurin
• tiazofurina
• tiazofurine
• tiazofurinum

Definition

A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a β-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).

References

• cas:60084-10-8
• kegg.drug:D06130
• pdb-ccd:TIZ
• pubmed:11249583
• pubmed:23764899
• pubmed:2712550
• pubmed:8667040
• reaxys:1084555
• wikipedia.en:Tiazofurin

Ontology

ChEBI  ( EBI )

Resources

CTD