tandutinib

Term ID

CHEBI:90237

Synonyms

• (4-(6-methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
• 4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide
• CT 53518
• CT-53518
• CT53518
• MLN 518
• MLN-518
• MLN518
• tandutinib
• tandutinibum

Definition

An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 is replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

References

• cas:387867-13-2
• drugbank:DB05465
• kegg.drug:D06005
• lincs.smallmolecule:LSM-5949
• pubmed:12124172
• pubmed:17962760
• pubmed:18175263
• pubmed:20711630
• pubmed:22146535
• pubmed:23427297
• pubmed:23525656
• pubmed:23619284
• reaxys:9241203

Ontology

ChEBI  ( EBI )