Search Ontology:
ChEBI
selumetinib
- Term ID
- CHEBI:90227
- Synonyms
-
- 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
- ARRY 142886
- ARRY-142886
- ARRY142886
- AZD 6244
- AZD-6244
- AZD6244
- selumetinib
- selumetinibum
- Definition
- A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor.
- References
-
- cas:606143-52-6
- kegg.drug:D09666
- lincs.smallmolecule:LSM-1056
- pdb-ccd:3EW
- pubmed:20407895
- pubmed:20978926
- pubmed:21594619
- pubmed:22241789
- pubmed:22343622
- pubmed:22394161
- pubmed:22565394
- pubmed:22972589
- pubmed:23372439
- pubmed:23444215
- pubmed:23942066
- pubmed:25322874
- pubmed:25342139
- pubmed:25379021
- pubmed:25385055
- pubmed:25498501
- pubmed:25637165
- pubmed:25887099
- pubmed:26059332
- pubmed:26384399
- pubmed:26446942
- reaxys:11099648
- wikipedia.en:Selumetinib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from selumetinib
Phenotype where environments contain selumetinib
Phenotype modified by environments containing selumetinib
Phenotype affecting selumetinib
Human Disease Model