rubitecan

Term ID

CHEBI:90225

Synonyms

• (4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 9-NC
• 9-nitro-(20S)-camptothecin
• 9-nitro-20(S)-camptothecin
• 9-nitrocamptothecin
• Camptogen
• Orathecin
• RFS 2000
• rubitecan
• rubitecanum

Definition

A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

References

• cas:91421-42-0
• drugcentral:2411
• kegg.drug:D04031
• pubmed:10200331
• pubmed:11901310
• pubmed:15122081
• pubmed:15357630
• pubmed:16370935
• pubmed:21191594
• pubmed:21695227
• pubmed:23873658
• pubmed:23934323
• pubmed:24549232
• pubmed:25445521
• pubmed:26004006
• pubmed:26487893
• reaxys:5365063
• wikipedia.en:Rubitecan

Ontology

ChEBI  ( EBI )