rubitecan

Term ID

CHEBI:90225

Synonyms

(4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
9-NC
9-nitro-(20S)-camptothecin
9-nitro-20(S)-camptothecin
9-nitrocamptothecin
Camptogen
Orathecin
RFS 2000
rubitecan
rubitecanum

Definition

A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: C-nitro compound delta-lactone pyranoindolizinoquinoline semisynthetic derivative tertiary alcohol

C-nitro compound delta-lactone pyranoindolizinoquinoline semisynthetic derivative tertiary alcohol Show first 5 Terms
has_role: antineoplastic agent EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug

antineoplastic agent EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from rubitecan

Phenotype where environments contain rubitecan

Phenotype modified by environments containing rubitecan

Human Disease / Model Data

Citations