plitidepsin

Term ID

CHEBI:90205

Synonyms

• 1-(2-oxopropanoyl)-L-prolyl-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-[(2S)-butan-2-yl]-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetra
• Aplidin
• Aplidine
• dehydrodidemnin B
• plitidepsin
• plitidepsina
• plitidepsine
• plitidepsium

Definition

A didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans.

References

• cas:137219-37-5
• drugbank:DB04977
• kegg.compound:C16862
• knapsack:C00044529
• patent:WO1991004985
• pubmed:16278386
• pubmed:18941750
• pubmed:19513942
• pubmed:19687728
• pubmed:21747745
• pubmed:22336911
• pubmed:23697951
• pubmed:24287622
• pubmed:24473171
• pubmed:25681727
• pubmed:25768401
• pubmed:33495306
• wikipedia.en:Plitidepsin

Ontology

ChEBI  ( EBI )