Search Ontology:
ChEBI

rac-selisistat

Term ID
CHEBI:90196
Synonyms
  • EX-527
  • rac-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
  • rac-EX-527
  • salisistat
  • selisistat
  • selisistatum
Definition
A racemate comprising equimolar amounts of (R)- and (S)-selisistat. It is a potent sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) and is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. The active isomer (EX-243) gives similar results and potency; the enantiomer (EX-242) is inactive.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
Phenotype
Phenotype resulting from rac-selisistat
Phenotype where environments contain rac-selisistat
Phenotype modified by environments containing rac-selisistat
Human Disease Model
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