cyclo(L-His-L-Pro)

Term ID

CHEBI:90039

Synonyms

(3S,8aS)-3-[(1H-imidazol-5-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
cyclo(His-Pro)
cyclo(histidyl-prolyl)
cyclo(L-His-L-Pro)
His-Pro-DKP
histidyl-proline diketopiperazine
histidyl-proline-diketopiperazine
histidylproline diketopiperazine
L,L-cyclo(histidylprolyl)
L-His-L-Pro-DKP
L-histidyl-L-proline diketopiperazine

Definition

A homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH).

References

cas:53109-32-3
foodb.food:FDB022818
hmdb:HMDB0002053
pdb-ccd:CHQ
pubmed:15509170
pubmed:21364307
pubmed:22185821
pubmed:2501708
pubmed:2512185
pubmed:27529240
pubmed:29708066
pubmed:3003820
pubmed:30439413
pubmed:3102558
pubmed:3129742
pubmed:3251576
pubmed:3840081
pubmed:6248056
pubmed:6278283
pubmed:6398951
pubmed:6401750
pubmed:6672793
pubmed:7679984

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from cyclo(L-His-L-Pro)

Phenotype where environments contain cyclo(L-His-L-Pro)

Phenotype modified by environments containing cyclo(L-His-L-Pro)

Phenotype affecting cyclo(L-His-L-Pro)

Human Disease Model