safrole

Term ID

CHEBI:8994

Synonyms

1,2-methylenedioxy-4-allylbenzene
1-allyl-3,4-methylenedioxybenzene
3,4-(methylenedioxy)allylbenzene
3-(3,4-methylenedioxyphenyl)prop-1-ene
4-allyl-1,2-methylenedioxybenzene
4-allylpyrocatechol formaldehyde acetal
5-(2-propenyl)-1,3-benzodioxole
5-allyl-1,3-benzodioxole
5-allyl-benzo[1,3]dioxole
allylcatechol methylene ether
m-allylpyrocatechin methylene ether
safrol
shikimol
shikimole

Definition

A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from safrole

Phenotype where environments contain safrole

Phenotype modified by environments containing safrole

Human Disease Model