Search Ontology:
ChEBI

SN-38

Term ID
CHEBI:8988
Synonyms
  • (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-Hydroxy-7-ethylcamptothecin
  • 7-Ethyl-10-hydroxy-20(S)-camptothecin
  • 7-Ethyl-10-hydroxycamptothecin
  • NK 012
  • NK-012
  • SN 38
  • SN 38 lactone
  • SN-38
(all 9)
Definition
A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
References
(all 41)
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
inverse has_functional_parent
Phenotype
Phenotype resulting from SN-38
Phenotype where environments contain SN-38
Phenotype modified by environments containing SN-38
Phenotype affecting SN-38
Human Disease Model
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