Search Ontology:
ChEBI
SN-38
- Term ID
- CHEBI:8988
- Synonyms
-
- (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hydroxy-7-ethylcamptothecin
- 7-Ethyl-10-hydroxy-20(S)-camptothecin
- 7-Ethyl-10-hydroxycamptothecin
- NK 012
- NK-012
- SN 38
- SN 38 lactone
- SN-38
- Definition
- A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
- References
-
- cas:86639-52-3
- hmdb:HMDB0060510
- kegg.compound:C11173
- pdb-ccd:RS4
- pubmed:23921491
- pubmed:24194565
- pubmed:24477982
- pubmed:24494988
- pubmed:24842785
- pubmed:24990485
- pubmed:25233635
- pubmed:25910639
- pubmed:25917289
- pubmed:26080460
- pubmed:26106073
- pubmed:26330269
- pubmed:26337772
- pubmed:26381056
- pubmed:26505475
- pubmed:26518357
- pubmed:26526067
- pubmed:26529243
- pubmed:26541586
- pubmed:26656185
- pubmed:26695118
- pubmed:26728136
- pubmed:31321449
- pubmed:31707444
- pubmed:31956782
- pubmed:32032928
- pubmed:32104495
- pubmed:32385283
- pubmed:32387182
- pubmed:33125824
- pubmed:33138058
- pubmed:33475937
- pubmed:33615176
- pubmed:33774525
- pubmed:33851564
- reaxys:4829984
- wikipedia.en:SN-38
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from SN-38
Phenotype where environments contain SN-38
Phenotype modified by environments containing SN-38
Phenotype affecting SN-38
Human Disease Model