bryostatin 1

Term ID

CHEBI:88353

Synonyms

(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)
bryostatin-1

Definition

A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.

References

cas:83314-01-6
drugbank:DB11752
kegg.compound:C05149
knapsack:C00038654
pubmed:10502742
pubmed:14735696
pubmed:16834754
pubmed:20354984
pubmed:21175177
pubmed:22539107
pubmed:22579485
pubmed:22986161
pubmed:23146662
pubmed:23369356
pubmed:24291721
pubmed:24659806
pubmed:24674872
pubmed:24677503
pubmed:25299527
pubmed:25301233
pubmed:25472878
pubmed:25523423
pubmed:25808573
pubmed:26225566
pubmed:26563568
pubmed:26891037
pubmed:27068183
pubmed:27128726
pubmed:27472877
pubmed:27941949
pubmed:27994072
pubmed:28467486
pubmed:28472666
pubmed:28482641
pubmed:28539614
pubmed:28590053
pubmed:28934369
pubmed:29026042
pubmed:29066536
pubmed:29115558
pubmed:8477194
pubmed:9195893
pubmed:9225066
reaxys:4349157
wikipedia.en:Bryostatin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from bryostatin 1

Phenotype where environments contain bryostatin 1

Phenotype modified by environments containing bryostatin 1

Phenotype affecting bryostatin 1

Human Disease Model