CD437

Term ID

CHEBI:88334

Synonyms

• 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid
• 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]-2-naphthalenecarboxylic acid
• 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
• AHPN
• Apoptosis Activator VI
• Cd 437
• CD-437

Definition

A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)γ and induces cell cycle arrest and apoptosis in various cancer cells.

References

• cas:125316-60-1
• lincs.smallmolecule:LSM-6237
• pubmed:10942519
• pubmed:11526443
• pubmed:12566985
• pubmed:12581872
• pubmed:17474084
• pubmed:18936944
• pubmed:22446330
• pubmed:9846184
• reaxys:7445028

Ontology

ChEBI  ( EBI )