remikiren

Term ID

CHEBI:8803

Synonyms

N-[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-Nalpha-{(2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl}-L-histidinamide
Nalpha-[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-L-histidinamide
remikiren
remikirene
remikireno
remikirenum
Ro 42-5892
Ro-42-5892

Definition

An L-histidine derivative that is L-histidine in which one of the amino hydrogens is replaced by a (2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl group and the carboxy group is replaced by a [(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino group. It is a renin inhibitor which was under development for the treatment of hypertension (now discontinued).

References

cas:126222-34-2
chemspider:4884377
drugbank:DB00212
drugcentral:4696
hmdb:HMDB0014357
kegg.compound:C07465
kegg.drug:D09038
pdb-ccd:REM
pubmed:10809804
pubmed:1282588
pubmed:12959271
pubmed:1313478
pubmed:22193701
pubmed:26421414
pubmed:7564363
pubmed:7678159
pubmed:7692163
pubmed:7769797
pubmed:7795817
pubmed:8206619
pubmed:8207739
pubmed:8222499
pubmed:8228207
pubmed:8491068
pubmed:8498974
pubmed:8512659
pubmed:8730917
pubmed:8730920
pubmed:8730924
pubmed:8783774
pubmed:8851507
pubmed:9095095
pubmed:9172787
wikipedia.en:Remikiren

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from remikiren

Phenotype where environments contain remikiren

Phenotype modified by environments containing remikiren

Phenotype affecting remikiren

Human Disease Model