mycophenolate mofetil

Term ID

CHEBI:8764

Synonyms

2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
Cellcept
MMF
mycophenolic acid morpholinoethyl ester
RS 61443

Definition

A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.

References

cas:128794-94-5
drugbank:DB00688
drugcentral:1859
hmdb:HMDB0014826
kegg.compound:C07908
kegg.drug:D00752
pubmed:11099793
pubmed:11490743
pubmed:15572389
pubmed:15992049
pubmed:16979992
pubmed:19858585
pubmed:21180633
pubmed:21710356
pubmed:22081165
pubmed:22294686
pubmed:22310598
pubmed:22417996
pubmed:22460418
pubmed:22560143
pubmed:8826401
pubmed:9274835
reaxys:7500599
wikipedia.en:Mycophenolate_mofetil

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from mycophenolate mofetil

Phenotype where environments contain mycophenolate mofetil

Phenotype modified by environments containing mycophenolate mofetil

Phenotype affecting mycophenolate mofetil

Human Disease Model