quinapril

Term ID

CHEBI:8713

Synonyms

• (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• quinapril
• quinaprilum

Definition

A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the α-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.

References

• cas:85441-61-8
• drugbank:DB00881
• drugcentral:2340
• kegg.compound:C07398
• kegg.drug:D03752
• lincs.smallmolecule:LSM-3620
• patent:US4344949
• pubmed:17404826
• pubmed:27165572
• pubmed:27169890
• pubmed:29980144
• wikipedia.en:Quinapril

Ontology

ChEBI  ( EBI )