pyrimethamine

Term ID

CHEBI:8673

Synonyms

• 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
• 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
• 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
• 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
• 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
• CD
• Chloridine
• Chloridyn
• Diaminopyritamin
• Ethylpyrimidine
• pirimetamina
• Primethamine
• pyrimethamine
• pyrimethaminum

Definition

An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

References

• cas:58-14-0
• drugbank:DB00205
• hmdb:HMDB0014350
• kegg.compound:C07391
• kegg.drug:D00488
• lincs.smallmolecule:LSM-3967
• pdb-ccd:CP6
• pubmed:11257045
• pubmed:11313656
• pubmed:12543697
• pubmed:16157660
• pubmed:19435820
• pubmed:28166217
• pubmed:3377143
• reaxys:219864
• vsdb:1912
• wikipedia.en:Pyrimethamine

Ontology

ChEBI  ( EBI )

Resources

CTD