palbociclib

Term ID

CHEBI:85993

Synonyms

• 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
• 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
• IBRANCE
• palbociclib
• PD 0332991
• PD 332991
• PD-0332991
• PD0332991
• UNII-G9ZF61LE7G

Definition

A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.

References

• cas:571190-30-2
• kegg.drug:D10372
• pdb-ccd:LQQ
• pubmed:25417786
• pubmed:25494820
• pubmed:25501126
• pubmed:25522918
• pubmed:25524798
• pubmed:25744718
• pubmed:25792301
• pubmed:25813205
• pubmed:26030518
• pubmed:26036642
• reaxys:10219048
• wikipedia.en:Palbociclib

Ontology

ChEBI  ( EBI )