panobinostat

Term ID

CHEBI:85990

Synonyms

(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
LBH 589
LBH589
panobinostat

Definition

A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: cinnamamides hydroxamic acid methylindole secondary amino compound

cinnamamides hydroxamic acid methylindole secondary amino compound Show first 5 Terms
has_role: angiogenesis modulating agent antineoplastic agent EC 3.5.1.98 (histone deacetylase) inhibitor

angiogenesis modulating agent antineoplastic agent EC 3.5.1.98 (histone deacetylase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: panobinostat(1+)

panobinostat(1+) Show first 5 Terms
is_conjugate_base_of: panobinostat(1+)

panobinostat(1+) Show first 5 Terms

Phenotype

Phenotype resulting from panobinostat

Phenotype where environments contain panobinostat

Phenotype modified by environments containing panobinostat

Human Disease Model