Search Ontology:
ChEBI

proguanil

Term ID
CHEBI:8455
Synonyms
  • 1-(p-chlorophenyl)-5-isopropylbiguanide
  • Chlorguanide
  • Chloroguanide
  • N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
  • N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
  • proguanil
  • proguanilum
Definition
A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from proguanil
Phenotype where environments contain proguanil
Phenotype modified by environments containing proguanil
Human Disease Model
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