trabectedin

Term ID

CHEBI:84050

Synonyms

• (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl ace
• Ect 743
• Ecteinascidin
• Ecteinascidin 743
• ET-743
• ET743
• trabectedin
• Yondelis

Definition

A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.

References

• cas:114899-77-3
• drugbank:DB05109
• drugcentral:4633
• hmdb:HMDB0015609
• kegg.compound:C16875
• kegg.drug:D06199
• pubmed:18728699
• pubmed:21403840
• pubmed:21499557
• pubmed:23149213
• pubmed:24001124
• pubmed:24277455
• pubmed:24662672
• pubmed:24692579
• pubmed:24696229
• pubmed:24707261
• pubmed:24755886
• pubmed:24756367
• pubmed:24803896
• pubmed:24844217
• pubmed:24917554
• pubmed:24941346
• pubmed:24982387
• pubmed:25048043
• pubmed:25048044
• pubmed:25050069
• pubmed:25076252
• pubmed:25100135
• pubmed:25209722
• pubmed:25263179
• pubmed:25273374
• pubmed:25479910
• reaxys:7617615
• wikipedia.en:Trabectedin

Ontology

ChEBI  ( EBI )

Resources

CTD