MDL-28170

Term ID

CHEBI:82818

Synonyms

benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}butan-2-yl]carbamate
calpain inhibitor III
carbobenzoxyvalylphenylalanine aldehyde
Cbz-Val-Phe-H
CbzValPheH
L-benzyloxycarbonyl-L-valyl-L-phenylalaninal
MDL 28,170
MDL 28170
MDL-28170
MDL28170
N-benzyloxycarbonyl-L-valyl-L-phenylalaninal
N-benzyloxycarbonylvalylphenylalaninal
N-benzyloxycarbonylvalylphenylalanine aldehyde
N-CBZ-Val-Phe-al
Z-Val-Phe-al
Z-Val-Phe-CHO
Z-Val-Phe-H

Definition

A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a γ-secretase inhibitor.

References

cas:88191-84-8
lincs.smallmolecule:LSM-2958
pubmed:12001809
pubmed:12820680
pubmed:15275793
pubmed:15282090
pubmed:15777753
pubmed:16817871
pubmed:16842979
pubmed:17600513
pubmed:20657463
pubmed:20874056
pubmed:22077394
pubmed:22253611
pubmed:22356295
pubmed:26087461
pubmed:2849930
pubmed:28663009
pubmed:29039273
pubmed:29728827
pubmed:30528875
pubmed:30876457
pubmed:31198938
pubmed:31618932
pubmed:35202224
pubmed:37090078
pubmed:37484825
pubmed:39326733
pubmed:39591265
pubmed:9302348
pubmed:9637399
reaxys:6824325

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from MDL-28170

Phenotype where environments contain MDL-28170

Phenotype modified by environments containing MDL-28170

Phenotype affecting MDL-28170

Human Disease Model