syrbactin

Term ID

CHEBI:82671

Synonyms

syrbactins

Definition

A class of azamacrocyclic natural products with a 2,7-dioxo-1,6-diazacyclododecane skeleton that includes the syringolin, glidobactin and cepafungin natural product families. In addition to their related molecular frameworks, members of the class share similar biosynthesis pathways and identical modes-of-action, being irreversible proteasome inhibitor that inhibit all three activities of eukaryotic proteasomes.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: azamacrocycle lactam

azamacrocycle lactam Show first 5 Terms
has subtype: syringolin A

syringolin A Show first 5 Terms
has_role: metabolite proteasome inhibitor

metabolite proteasome inhibitor Show first 5 Terms
inverse has_functional_parent: luminmycin A

luminmycin A Show first 5 Terms

Phenotype

Phenotype resulting from syrbactin

Phenotype where environments contain syrbactin

Phenotype modified by environments containing syrbactin

Human Disease Model