pemoline

Term ID

CHEBI:7953

Synonyms

• 2-amino-5-phenyl-1,3-oxazol-4(5H)-one
• 2-Amino-5-phenyl-4(5H)-oxazolone
• 2-imino-4-keto-5-phenyltetrahydrooxazole
• 2-imino-5-phenyl-4-oxazolidinone
• 5-phenyl-2-imino-4-oxazolidinone
• 5-phenyl-2-imino-4-oxooxazolidine
• 5-phenylisohydantion
• Azoxodon
• Betanamin
• Cylert
• Dantromin
• Deltamine
• Hyton
• Myamin
• Nitan
• Notair
• pemolina
• pemoline
• pemolinum
• pheniminooxazolidinone
• phenylisohydantoin
• phenylpseudohydantoin

Definition

A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.

References

• cas:2152-34-3
• drugbank:DB01230
• drugcentral:2075
• kegg.compound:C07899
• kegg.drug:D00744
• lincs.smallmolecule:LSM-5159
• pubmed:11216184
• pubmed:2210262
• pubmed:2303976
• pubmed:2388127
• pubmed:4021028
• pubmed:641739
• pubmed:772696
• reaxys:151559
• wikipedia.en:Pemoline

Ontology

ChEBI  ( EBI )

Resources

CTD