paroxetine

Term ID

CHEBI:7936

Synonyms

(-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
paroxetina
Paroxetine
paroxetinum

Definition

A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether benzodioxoles organofluorine compound piperidines

aromatic ether benzodioxoles organofluorine compound piperidines Show first 5 Terms
has_functional_parent: monofluorobenzene

monofluorobenzene Show first 5 Terms
has_role: antidepressant anxiolytic drug hepatotoxic agent P450 inhibitor serotonin uptake inhibitor

antidepressant anxiolytic drug hepatotoxic agent P450 inhibitor serotonin uptake inhibitor Show first 5 Terms
inverse has_functional_parent: N-methylparoxetine

N-methylparoxetine Show first 5 Terms
inverse is_conjugate_acid_of: paroxetinium(1+)

paroxetinium(1+) Show first 5 Terms
is_conjugate_base_of: paroxetinium(1+)

paroxetinium(1+) Show first 5 Terms

Phenotype

Phenotype resulting from paroxetine

Phenotype where environments contain paroxetine

Phenotype modified by environments containing paroxetine

Human Disease Model