paroxetine

Term ID

CHEBI:7936

Synonyms

(-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
paroxetina
Paroxetine
paroxetinum

Definition

A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT_2A, 5-HT_1A, D₂ or H₁ receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

References

cas:61869-08-7
drugbank:DB00715
drugcentral:2068
kegg.compound:C07415
kegg.drug:D02362
lincs.smallmolecule:LSM-2843
pubmed:11009210
pubmed:11169163
pubmed:11271409
pubmed:11281965
pubmed:11324355
pubmed:11360029
pubmed:11513198
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pubmed:17452166
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pubmed:17652957
pubmed:17874333
pubmed:18273418
pubmed:18345955
pubmed:18808757
pubmed:18983224
pubmed:19687003
pubmed:19851065
pubmed:21404089
pubmed:21452176
pubmed:21739267
pubmed:21908494
pubmed:21909633
pubmed:21922171
pubmed:21939725
pubmed:22153922
pubmed:22198456
pubmed:22212003
pubmed:22240860
pubmed:22263916
pubmed:22283559
pubmed:22353759
pubmed:22377745
reaxys:7467879
wikipedia.en:Paroxetine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from paroxetine

Phenotype where environments contain paroxetine

Phenotype modified by environments containing paroxetine

Phenotype affecting paroxetine

Human Disease Model