paromomycin

Term ID

CHEBI:7934

Synonyms

(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
Aminosidin
aminosidine
Catenulin
crestomycin
estomycin
Hydroxymycin
Monomycin A
Neomycin E
paromomicina
PAROMOMYCIN
Paromomycin I
paromomycine
paromomycinum
paucimycin
paucimycinum
R 400
R-400
Zygomycin A1

Definition

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

References

CAS:7542-37-2
DrugBank:DB01421
Drug_Central:2067
KEGG:C00832
KEGG:D07467
PDBeChem:PAR
PMID:18447603
PMID:18947845
PMID:8036682
Patent:US2895876
Patent:US2916485
Reaxys:72285

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from paromomycin

Phenotype where environments contain paromomycin

Phenotype modified by environments containing paromomycin

Phenotype affecting paromomycin

Human Disease Model