paromomycin

Term ID

CHEBI:7934

Synonyms

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
• Aminosidin
• aminosidine
• Catenulin
• crestomycin
• estomycin
• Hydroxymycin
• Monomycin A
• neomycin E
• paromomicina
• paromomycin
• Paromomycin I
• paromomycine
• paromomycinum
• paucimycin
• paucimycinum
• R 400
• R-400
• Zygomycin A1

Definition

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

References

• CAS:7542-37-2
• DrugBank:DB01421
• Drug_Central:2067
• KEGG:C00832
• KEGG:D07467
• PDBeChem:PAR
• PMID:18447603
• PMID:18947845
• PMID:8036682
• Patent:US2895876
• Patent:US2916485
• Reaxys:72285

Ontology

ChEBI  ( EBI )

Resources

CTD