pederin

Term ID

CHEBI:78591

Synonyms

(+)-pederin
(+)-pederine
(2S)-N-[(S)-{(2S,4R,6R)-6-[(2S)-2,3-dimethoxypropyl]-4-hydroxy-5,5-dimethyltetrahydro-2H-pyran-2-yl}(methoxy)methyl]-2-hydroxy-2-[(2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl]acetamide
paederine
pederine

Definition

A polyketide and carboxamide produced by a (Pseudomonas) bacterial endosymbiont of certain rove beetles (genus Paederus). Pederin is the agent responsible for the vesicant effects (linear or Paederus dermatitis) when the beetle is crushed against the skin. It is a powerful inhibitor of protein biosynthesis and mitosis and a potent antitumour agent.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: cyclic ketal diol oxanes polyketide secondary alcohol ... Show All 6 Terms

cyclic ketal diol oxanes polyketide secondary alcohol secondary carboxamide Show first 5 Terms
has_role: antimitotic antineoplastic agent bacterial metabolite vesicant

antimitotic antineoplastic agent bacterial metabolite vesicant Show first 5 Terms

Phenotype

Phenotype resulting from pederin

Phenotype where environments contain pederin

Phenotype modified by environments containing pederin

Human Disease / Model Data

Citations