ceritinib

Term ID

CHEBI:78432

Synonyms

• 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
• ceritinib
• ceritinibum
• ZYKADIA

Definition

A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.

References

• cas:1032900-25-6
• drugcentral:4866
• lincs.smallmolecule:LSM-36374
• pubmed:24670165
• pubmed:24675041
• pubmed:24789171
• pubmed:24856155
• pubmed:24891360
• pubmed:24963575
• pubmed:24963576
• pubmed:24980964
• pubmed:24984564
• pubmed:24998601
• pubmed:25002599
• reaxys:18383989
• wikipedia.en:Ceritinib

Ontology

ChEBI  ( EBI )