icariin

Term ID

CHEBI:78420

Synonyms

3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
ieariline

Definition

A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-α-L-mannopyranoside, methyl ether, and β-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).

References

cas:489-32-7
kegg.compound:C17555
lincs.smallmolecule:LSM-3462
lipidmaps:LMPK12112009
pubmed:16380159
pubmed:16751992
pubmed:17120748
pubmed:17142971
pubmed:17169663
pubmed:17355822
pubmed:17419678
pubmed:17482445
pubmed:17499557
pubmed:17509675
pubmed:17557750
pubmed:17600559
pubmed:17613817
pubmed:17764702
pubmed:18053336
pubmed:18398927
pubmed:18501540
pubmed:18778098
pubmed:22216122
pubmed:23772748
pubmed:23824956
pubmed:23975599
pubmed:24265111
pubmed:24295650
pubmed:24311544
pubmed:24435883
pubmed:24462390
pubmed:24552978
pubmed:24590261
pubmed:24619236
pubmed:24710854
pubmed:24748177
reaxys:76280
wikipedia.en:Icariin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from icariin

Phenotype where environments contain icariin

Phenotype modified by environments containing icariin

Phenotype affecting icariin

Human Disease Model