PP2

Term ID

CHEBI:78331

Synonyms

1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
AG 1879
AG-1879
AG1879

Definition

A member of the class of pyrazolopyrimidine that is pyrazolo[3,4-d]pyrimidin-4-amine bearing additional tert-butyl and 4-chlorophenyl substituents at positions 1 and 3 respectively. It is a potent ATP-competitive inhibitor of the Src family of protein tyrosine kinases.

References

cas:172889-27-9
lincs.smallmolecule:LSM-4153
pdb-ccd:PP2
pubmed:22363408
pubmed:24183378
pubmed:24566462
pubmed:24735922
pubmed:31340912
reaxys:9409964
wikipedia.en:PP2_(kinase_inhibitor)

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from PP2

Phenotype where environments contain PP2

Phenotype modified by environments containing PP2

Phenotype affecting PP2

Human Disease Model