huperzine A

Term ID

CHEBI:78330

Synonyms

(-)-huperazine A
(-)-selagine
(5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
(5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
Hup A
HupA
huperzine-A
hupzine A
kimpukan A
selagine

Definition

A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.

References

agr:IND606941294
cas:102518-79-6
chemspider:16736021
drugbank:DB04864
hmdb:HMDB0242654
knapsack:C00028361
pubmed:12895686
pubmed:23306162
pubmed:24129696
pubmed:24190328
pubmed:24299147
pubmed:24332448
pubmed:24639880
pubmed:31305343
pubmed:31922239
pubmed:31990212
pubmed:32052235
pubmed:32576772
pubmed:32708929
pubmed:32729341
pubmed:32869005
pubmed:32970179
pubmed:32970952
pubmed:33252842
pubmed:33278032
pubmed:33504676
pubmed:33567664
pubmed:33675928
pubmed:33708959
pubmed:33851462
pubmed:33891962
pubmed:33930191
pubmed:34072855
pubmed:34198639
pubmed:34306441
pubmed:34363318
pubmed:34368579
pubmed:34419561
reaxys:3592896
wikipedia.en:Huperzine_A

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from huperzine A

Phenotype where environments contain huperzine A

Phenotype modified by environments containing huperzine A

Phenotype affecting huperzine A

Human Disease Model