Search Ontology:
ChEBI

tilidine

Term ID
CHEBI:77823
Synonyms
  • ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • tilidina
  • tilidine
  • tilidinum
Definition
A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
Phenotype
Phenotype resulting from tilidine
Phenotype where environments contain tilidine
Phenotype modified by environments containing tilidine
Human Disease / Model Data
Citations
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