Search Ontology:
ChEBI

phosphorothioate oligonucleotide

Term ID
CHEBI:76674
Synonyms
  • oligo(nucleoside phosphorothioate)
  • oligo(nucleoside phosphorothioate)s
  • oligonucleotide phosphorothioate
  • oligonucleotide phosphorothioates
  • OPS
  • phosphorothioate DNA
  • phosphorothioate oligonucleotides
  • PS DNA
  • PS-DNA
  • S-oligo
  • S-oligos
Definition
An oligonucleotide in which one of the non-bridging oxygens in each phosphodiester linkage has been replaced by sulfur. The main application of phosphorothioate linkages in an oligonucleotide is to protect the oligonucleotide from nuclease degradation.
References
  • pubmed:9746230
  • wikipedia.en:Oligonucleotide_synthesis#Oligonucleotide_phosphorothioates_and_their_synthesis
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from phosphorothioate oligonucleotide
Phenotype where environments contain phosphorothioate oligonucleotide
Phenotype modified by environments containing phosphorothioate oligonucleotide
Phenotype affecting phosphorothioate oligonucleotide
Human Disease Model
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