Search Ontology:
ChEBI
ACT-132577
- Term ID
- CHEBI:76609
- Synonyms
-
- N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide
- Definition
- A member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension.
- References
-
- patent:US2008233188
- patent:WO2007119214
- patent:WO2008026156
- pubmed:18780830
- pubmed:19765655
- pubmed:21541781
- pubmed:22189899
- pubmed:23568224
- pubmed:23817130
- pubmed:23900878
- pubmed:24122797
- reaxys:11340634
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from ACT-132577
Phenotype where environments contain ACT-132577
Phenotype modified by environments containing ACT-132577
Phenotype affecting ACT-132577
Human Disease Model