flunoxaprofen

Term ID

CHEBI:76154

Synonyms

• (+)-2-(p-Fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
• (2S)-2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
• (S)-(+)-Flunoxaprofen
• (S)-2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
• flunoxaprofen
• flunoxaprofene
• flunoxaprofeno
• flunoxaprofenum

Definition

A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.

References

• cas:66934-18-7
• drugcentral:1203
• kegg.drug:D07219
• pubmed:1469334
• pubmed:1686227
• pubmed:19370733
• pubmed:1950816
• pubmed:19773537
• pubmed:19786506
• pubmed:2533024
• pubmed:2626206
• pubmed:2671808
• pubmed:2748505
• pubmed:2762365
• pubmed:3196413
• pubmed:3401272
• pubmed:3403103
• pubmed:3566853
• pubmed:3596866
• pubmed:3627532
• pubmed:3670687
• pubmed:3836872
• pubmed:3888865
• pubmed:4018949
• pubmed:8985978
• reaxys:6871045
• wikipedia.en:Flunoxaprofen

Ontology

ChEBI  ( EBI )

Resources

CTD