teniposide

Term ID

CHEBI:75988

Synonyms

• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside
• HSDB 6546
• NSC 122819
• NSC-122819
• teniposide
• teniposido
• teniposidum
• VM-26
• VM26
• Vumon

Definition

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.

References

• cas:29767-20-2
• drugbank:DB00444
• drugcentral:2590
• hmdb:HMDB0014587
• kegg.compound:C11153
• kegg.drug:D02698
• metacyc.compound:CPD-16755
• pdb-ccd:9TP
• pubmed:1063066
• pubmed:11516526
• pubmed:1329226
• pubmed:1411642
• pubmed:1411643
• pubmed:21430063
• pubmed:21821840
• pubmed:22644709
• pubmed:22771706
• pubmed:22846410
• pubmed:23266449
• pubmed:23466610
• pubmed:23679827
• pubmed:23838380
• pubmed:24969912
• pubmed:25151861
• pubmed:25448575
• pubmed:25899285
• pubmed:26253377
• pubmed:27596115
• pubmed:30409428
• pubmed:32015321
• pubmed:32194707
• reaxys:1417328
• wikipedia.en:Teniposide

Ontology

ChEBI  ( EBI )

Resources

CTD