nimodipine

Term ID

CHEBI:7575

Synonyms

• 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
• 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• BAY e 9736
• isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
• isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• Nimodipine
• nimodipino
• nimodipinum
• Nimotop
• Periplum

Definition

A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

References

• cas:66085-59-4
• drugbank:DB00393
• drugcentral:1937
• kegg.compound:C07267
• kegg.drug:D00438
• lincs.smallmolecule:LSM-1659
• patent:DE2117571
• patent:US3799934
• pubmed:12137606
• pubmed:16180362
• pubmed:17110283
• pubmed:21869451
• pubmed:22262041
• pubmed:22300914
• pubmed:8519001
• reaxys:459792
• wikipedia.en:Nimodipine

Ontology

ChEBI  ( EBI )

Resources

CTD