neurotensin

Term ID

CHEBI:7542

Synonyms

• 5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu
• 5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu-OH
• 5-oxo-L-prolyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
• Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
• L-Pyr-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu
• L-pyroglutamyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparagyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
• neurotensin
• neurotensin (1-13)
• neurotensin 1-13
• neurotensin-(1-13)
• Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

Definition

A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.

References

• cas:39379-15-2
• cas:55508-42-4
• cas:58889-67-1
• kegg.compound:C01836
• pubmed:17000667
• pubmed:21124211
• pubmed:21549161
• pubmed:23526754
• pubmed:25189338
• pubmed:25215420
• pubmed:26453765
• pubmed:27173113
• pubmed:28316623
• pubmed:28341345
• pubmed:28887225
• pubmed:29333632
• pubmed:29938867
• pubmed:30279001
• pubmed:31079844
• pubmed:31204518
• pubmed:32057800
• pubmed:32151680
• pubmed:32168264
• pubmed:32275927
• wikipedia.en:Neurotensin

Ontology

ChEBI  ( EBI )

Resources

CTD