Search Ontology:
ChEBI
formestane
- Term ID
- CHEBI:75172
- Synonyms
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- 4-hydroxy-4-androstene-3,17-dione
- 4-hydroxy-Delta(4)-androstenedione
- 4-hydroxyandrost-4-ene-3,17-dione
- 4-hydroxyandrostenedione
- 4-OH-A
- 4-OHAD
- CGP 32349
- CGP-32349
- formestane
- formestano
- formestanum
- Lentaron
- Definition
- A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
- References
-
- CAS:566-48-3
- DrugBank:DB08905
- Drug_Central:1238
- KEGG:D07260
- PMID:1419285
- PMID:1637664
- PMID:17207827
- PMID:22354842
- PMID:23339113
- PMID:6665821
- Reaxys:4198373
- Wikipedia:Formestane
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_parent_hydride
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from formestane
Phenotype where environments contain formestane
Phenotype modified by environments containing formestane
Human Disease / Model Data
Citations