acivicin

Term ID

CHEBI:74545

Synonyms

(2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
(alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
(alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid
acivicin
acivicine
acivicino
acivicinum
Antibiotic AT 125
AT 125
AT-125
NSC 163501
NSC-163501
U 42126
U-42,126

Definition

An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: isoxazoles non-proteinogenic L-alpha-amino acid organochlorine compound

isoxazoles non-proteinogenic L-alpha-amino acid organochlorine compound Show first 5 Terms
has_role: antileishmanial agent antimetabolite antimicrobial agent antineoplastic agent EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor ... Show All 7 Terms

antileishmanial agent antimetabolite antimicrobial agent antineoplastic agent EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor glutamine antagonist metabolite Show first 5 Terms

Phenotype

Phenotype resulting from acivicin

Phenotype where environments contain acivicin

Phenotype modified by environments containing acivicin

Human Disease / Model Data

Citations